Scientific Meeting report: International Biochemistry of Exercise 2022
Exercise is one of the only non-pharmacologic remedies known to counteract genetic and chronic diseases by enhancing health and improving life span. Although the many benefits of regular physical activity have been recognized for some time, the intricate and complex signalling system triggered at the onset of exercise have only recently begun to be uncovered. Exercising muscles initiate a coordinated, multisystemic, metabolic rewiring which is communicated to distant organs by various molecular mediators, including extracellular vesicles such as exosomes. The field of exercise research has been expanding beyond the musculoskeletal system, with interest from industry to provide realistic models and exercise mimetics that evoke a whole-body rejuvenation response. This year’s 18th International Biochemistry of Exercise conference took place in Toronto, Canada, from May 25th to May 28th, 2022, with more than 400 attendees. Here we provide an overview of the most cutting-edge exercise-related research presented by 66 speakers, focusing on new developments in topics ranging from molecular and cellular mechanisms of exercise adaptations, diabetes, and aging. We also provide descriptions on how manipulation of these signaling pathways provide therapeutic avenues for improving human health and quality of life…
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